A Novel Mechanism to Drive Castration-Resistant Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-resistant prostate cancer (CRPC). The development of CRPC is dependent upon the intratumoral generation of the potent androgen, dihydrotestosterone ...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2018
ISSN: 1043-2760
DOI: 10.1016/j.tem.2018.03.006